The vast majority of tRNAs in cells harbor a 3' CCA tail, essential for amino acid loading. Chantal found that in EVs, full-length tRNAs lacking an intact CCA are the most abundant small RNAs => EVs as tiny tRNA trash bags😉? Check out Chantal's preprint on bioRxiv!


A great review on the interplay between chromatin and the regulation of RNA Pol III-dependent genes written by Marlize (van Leeuwen lab) just appeared online in Biochemical Society Transactions!


Our project 'Decoding the emerging role of dynamic tRNA gene regulation in cancer and cellular adaptions to changing environments' in collaboration with the group of Prof Fred van Leeuwen at the NKI is among the 29 innovative collaborative research projects funded by ZonMW in the 2023 Open Competition round! More info here or here. Two PhD positions will be open soon (1 at the NKI, 1 at Amsterdam UMC - CCA).


Welcome to Yvette who joined us for a master internship. Yvette will work on the reciprocal regulation between a protein-coding and a tRNA gene under the supervision of Boris.

2023 ▼


Boris wins the best poster award of OddPols 2023, the International Conference on Transcription Mechanism and Regulation by archaeal RNA Polymerases and eukaryotic RNA Polymerases I, III, IV, and V that took place in Jaen (Spain). 

Congrats to Boris!


Trisha wins 2nd best poster prize at the VU Biomedical Sciences bachelor poster day! Congrats to Trisha (and her daily supervisor Boris!)


Chantal strikes again! Congrats to Cristina (Exosome Research Group) and Chantal on the publication of the NORMSEQ manuscript in NAR! NORMSEQ, a tool for evaluation, selection and visualization of RNA-Seq normalization methods, is available here.


Our review, written in collaboration with Evelina Tutucci, Sander van Otterdijk and Frank Bruggeman (VU Amsterdam, Systems Biology lab), on Understanding spatiotemporal coupling of gene expression using single molecule RNA imaging technologies is online


Chantal's manuscript on the development of ALL-tRNAseq for the robust profiling of tRNA expression in tissue samples is online on the Genes & Development website! Congrats to Chantal!


Welcome to Maurice and Trisha who joined us for their master and bachelor internship respectively.

2021-2022 ▼


Welcome to Fraser Johnson! Fraser joins the group as a Post-doc to work on the development of a screening procedure to identify oncogenic RAS inhibitors.


We received a KWF (Dutch Cancer Society) grant for our project 'Finding the key to inactivate oncogenic RAS mutants'! More info


Our project 'Precision targeting of aminoacyl-tRNA-synthetase in cancer' is among the 9 projects funded by the Cancer Center Amsterdam Foundation! 

More info here and here