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Welcome to our website! Our group is part of the Neuro-oncology Research Group (NRG) in the Department of Neurosurgery at the Cancer Center Amsterdam (Amsterdam UMC). Our interest is focused on understanding how genes transcribed by RNA Polymerase III are (mis)regulated in cancer cells, particularly tRNA genes in glioblastoma. Our goal is to understand how differential regulation of these genes promotes proliferation and/or oppose cell differentiation and how to interfere with these processes to impair cancer cell survival or proliferation. We combine fundamental research in cell and molecular biology coupled with advanced screening technologies to uncover the functions of these small non-coding genes with the aim to translate this knowledge into future clinical applications. More info
News
14.08.2026
Yoran's preprint is out! The study shows that early resistance to EGFR inhibitors in glioblastoma is not driven by broad rewiring of kinase signaling, but instead by reactivation of EGFR signaling itself. Increased EGFR abundance during treatment may help sustain this signaling and contribute to therapy resistance.
3.03.2026
Welcome to Stacey, Daniela and Ginger who will perform their Master internship with us for the next couple of months!
1.05.2025
Welcome to Maaike who joined us to investigate the cause(s) and consequences of the overexpression of specific tRNAs in glioblastoma thanks to an Amsterdam UMC Starter Grant.
3.03.2025
Welcome to Zeynep who joined us for a master internship. Zeynep will investigate functionally the relationship between tRNA levels, tRNA loading and amino acid metabolism in glioblastoma.
9.12.2024
We moved the lab to the new RDC ADORE building! Great way to end 2024!
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