Welcome

Welcome to our website! Our group is part of the Neuro-oncology Research Group (NRG) in the Department of Neurosurgery at the Cancer Center Amsterdam (Amsterdam UMC, location VUmc). Our interest is focused on understanding how genes transcribed by RNA Polymerase III are (mis)regulated in cancer cells, particularly tRNA genes in glioblastoma. Our goal is to understand how differential regulation of these genes promotes proliferation and/or oppose cell differentiation and how to interfere with these processes to impair cancer cell survival or proliferation. We combine fundamental research in cell and molecular biology coupled with advanced screening technologies to uncover the functions of these small non-coding genes with the aim to translate this knowledge into future clinical applications. More info