Welcome to our website! Our group is part of the Neuro-oncology Research Group (NRG) in the Department of Neurosurgery at the Cancer Center Amsterdam (Amsterdam UMC, location VUmc). Our interest is focused on understanding how genes transcribed by RNA Polymerase III are (mis)regulated in cancer cells, particularly tRNA genes in glioblastoma. Our goal is to understand how differential regulation of these genes promotes proliferation and/or oppose cell differentiation and how to interfere with these processes to impair cancer cell survival or proliferation. We combine fundamental research in cell and molecular biology coupled with advanced screening technologies to uncover the functions of these small non-coding genes with the aim to translate this knowledge into future clinical applications. More info
Trisha wins 2nd best poster prize at the VU Biomedical Sciences bachelor poster day! Congrats to Trisha (and her daily supervisor Boris!)
Chantal strikes again! Congrats to Cristina (Exosome Research Group) and Chantal on the publication of the NORMSEQ manuscript in NAR! NORMSEQ, a tool for evaluation, selection and visualization of RNA-Seq normalization methods, is available here.
Our review, written in collaboration with Evelina Tutucci, Sander van Otterdijk and Frank Bruggeman (VU Amsterdam, Systems Biology lab), on Understanding spatiotemporal coupling of gene expression using single molecule RNA imaging technologies is online!
Chantal's manuscript on the development of ALL-tRNAseq for the robust profiling of tRNA expression in tissue samples is online on the Genes & Development website! Congrats to Chantal!